Author:
Brun Victoria L.,Corbel Amanda F.,Hsing Ann W.,Kemp Troy J.,Van Dyke Alison L.,Hildesheim Allan,Zhu Bin,Gao Yu-Tang,Pinto Ligia A.,Koshiol Jill
Abstract
AbstractElevated systemic levels of soluble cluster of differentiation 14 (sCD14) have been associated with gallbladder cancer (GBC), but the association with sCD14 levels within the gallbladder has not been investigated. Here, we evaluated sCD14 in the bile of 41 GBC cases and 117 gallstone controls with data on 65 bile inflammation markers. We examined the relationship between bile sCD14 levels and GBC using logistic regression and stratified the analysis by stage. We included GBC-associated inflammatory biomarkers in the model to evaluate the influence of local inflammation. Bile sCD14 levels (third versus first tertile) were associated with GBC (adjusted odds ratio [OR]: 3.0, 95% confidence interval [CI]: 1.2–8.0). The association was equally strong for stage I/II (OR: 3.3, 95% CI: 0.9–15.6) and stage III/IV (OR: 3.2, 95% CI: 1.0–12.4) cancers. Including the GBC-associated inflammatory markers in the model removed the association between bile sCD14 and GBC (OR: 1.0, 95% CI: 0.3–3.5). The findings suggest that immune activation within the gallbladder may be related to GBC development, and the effect of sCD14 is influenced by inflammation. Similar associations across tumor stages suggest that elevated bile sCD14 levels may reflect changes early in GBC pathogenesis. Associations between GBC and sCD14 levels in both bile and plasma suggest sCD14 could be a potential biomarker for GBC.
Funder
Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics
National Cancer Institute
Publisher
Springer Science and Business Media LLC
Reference51 articles.
1. Espinoza, J. A. et al. The inflammatory inception of gallbladder cancer. Biochim. Biophys. Acta 1865(2), 245–254 (2016).
2. Lai, C. H. & Lau, W. Y. Gallbladder cancer–a comprehensive review. Surgeon. 6(2), 101–110 (2008).
3. Liu, E. et al. Aspirin use and risk of biliary tract cancer: A population-based study in Shanghai, China. Cancer Epidemiol. Biomark. Prev. 14(5), 1315–1318 (2015).
4. Jackson, S. S. et al. Association between aspirin use and biliary tract cancer survival. JAMA Oncol. 5(12), 1802–1804 (2019).
5. Shive, C. L., Jiang, W., Anthony, D. D. & Lederman, M. M. Soluble CD14 is a nonspecific marker of monocyte activation. AIDS 29(10), 1263–1265 (2015).
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