Author:
Atkinson-Clement Cyril,Tarrano Clement,Porte Camille-Albane,Wattiez Nicolas,Delorme Cécile,McGovern Eavan M.,Brochard Vanessa,Thobois Stéphane,Tranchant Christine,Grabli David,Degos Bertrand,Corvol Jean-Christophe,Pedespan Jean-Michel,Krystkoviak Pierre,Houeto Jean-Luc,Degardin Adrian,Defebvre Luc,Valabregue Romain,Rosso Charlotte,Apartis Emmanuelle,Vidailhet Marie,Pouget Pierre,Roze Emmanuel,Worbe Yulia
Abstract
AbstractMyoclonus-dystonia (MD) is a syndrome characterized by myoclonus of subcortical origin and dystonia, frequently associated with psychiatric comorbidities. The motor and psychiatric phenotypes of this syndrome likely result from cortico-striato-thamalo-cerebellar-cortical pathway dysfunction. We hypothesized that reactive and proactive inhibitory control may be altered in these patients. Using the Stop Signal Task, we assessed reactive and proactive inhibitory control in MD patients with (n = 12) and without (n = 21) deep brain stimulation of the globus pallidus interna and compared their performance to matched healthy controls (n = 24). Reactive inhibition was considered as the ability to stop an already initiated action and measured using the stop signal reaction time. Proactive inhibition was assessed through the influence of several consecutive GO or STOP trials on decreased response time or inhibitory process facilitation. The proactive inhibition was solely impaired in unoperated MD patients. Patients with deep brain stimulation showed impairment in reactive inhibition, independent of presence of obsessive–compulsive disorders. This impairment in reactive inhibitory control correlated with intrinsic severity of myoclonus (i.e. pre-operative score). The results point to a dissociation in reactive and proactive inhibitory control in MD patients with and without deep brain stimulation of the globus pallidus interna.
Funder
Agence Nationale de la Recherche
Dystonia Medical Research Foundation
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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