Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan

Author:

Lin Nan-Chin,Hsien Su-I,Hsu Jui-Ting,Chen Michael Y. C.

Abstract

AbstractThe incidence of oral cavity squamous cell carcinoma (OSCC) is particularly high in South Asia. According to the National Comprehensive Cancer Network, OSCC can arise in several subsites. We investigated survival rates and the clinical and pathological characteristics of OSCC in different anatomical subsites in the Taiwanese population. We retrospectively analyzed data for 3010 patients with OSCC treated at the Changhua Christian Hospital. Subsequently, we compared clinical and pathological features of OSCC in different subsites. Pathological T4 stage OSCCs occurred in the alveolar ridge and retromolar trigone in 56.4% and 43.7% of cases, respectively. More than 25% of patients with tongue OSCC and 23.4% of those with retromolar OSCC had lymph node metastasis. The prognosis was worst for hard palate OSCC (hazard ratio 1.848; p < 0.001) and alveolar ridge OSCC (hazard ratio 1.220; p = 0.017). Retromolar OSCC recurred most often and tongue OSCC second most often. The risk for cancer-related mortality was highest for hard palate OSCC, followed by alveolar ridge and retromolar OSCC. We found distinct differences in survival among the different subsites of OSCC. Our findings may also help prompt future investigations of OSCC in different subsites in Taiwanese patients.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference36 articles.

1. Ghantous, Y. & Abu Elnaaj, I. Global incidence and risk factors of oral cancer. Harefuah 156, 645–649 (2017).

2. Peres, M. A. et al. Oral diseases: A global public health challenge. Lancet 394, 249–260 (2019).

3. Thompson, L. World Health Organization classification of tumours: Pathology and genetics of head and neck tumours. Ear Nose Throat J. 85, 74 (2006).

4. Shah, J. P. & Gil, Z. Current concepts in management of oral cancer-surgery. Oral Oncol. 45, 394–401 (2009).

5. Kao, S. Y. & Lim, E. An overview of detection and screening of oral cancer in Taiwan, China. Chin. J. Dent. Res. 18, 7–12 (2015).

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