The Fab portion of immunoglobulin G contributes to its binding to Fcγ receptor III
Author:
Funder
Ministry of Education, Culture, Sports, Science and Technology
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-48323-w.pdf
Reference55 articles.
1. Dorrington, K. J. & Klein, M. H. Binding sites for Fcγ receptors on immunoglobulin G and factors influencing their expression. Mol Immunol 19, 1215–1221 (1982).
2. Burton, D. R. Immunoglobulin G: functional sites. Mol Immunol 22, 161–206 (1985).
3. Jefferis, R., Lund, J. & Pound, J. D. IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation. Immunol Rev 163, 59–76 (1998).
4. Yang, D., Kroe-Barrett, R., Singh, S., Roberts, C. J. & Laue, T. M. IgG cooperativity - Is there allostery? Implications for antibody functions and therapeutic antibody development. MAbs 9, 1231–1252 (2017).
5. Jay, J. W. B. et al. IgG Antibody 3D Structures and Dynamics. Antibodies 7 (2018).
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