Author:
Arıcan Emre Yağmur,Gökçeoğlu Kayalı Damla,Ulus Karaca Bahar,Boran Tuğçe,Öztürk Narin,Okyar Alper,Ercan Feriha,Özhan Gül
Abstract
AbstractAcetamiprid, a selective agonist of nicotinic acetylcholine recetors, is one of the most widely used neonicotinoids. There is limited data about toxicity of acetamiprid on male reproductive system. Therefore, the study aimed to investigate the reproductive toxic potential of acetamiprid in male rats orally treated with acetamiprid with low (12.5 mg/kg) medium (25 mg/kg) or high dose (35 mg/kg) for 90 days. According to our results, sperm concentration and plasma testosterone levels decreased in dose dependent manner. Gonadotropin-releasing hormone (GnRH), follicle-stimulating hormeone (FSH), luteinizing hormone (LH) levels increased at low and medium dose groups and acetamiprid caused lipid peroxidation and glutathione (GSH) depletion in the testes. Histologic examinations revealed that acetamiprid induced apoptosis in medium and high dose groups and proliferation index dramatically decreased in high dose group. In conclusion, acetamiprid caused toxicity on male reproductive system in the high dose. The mechanism of the toxic effect may be associated with oxidative stress, hormonal disruptions and apoptosis.
Publisher
Springer Science and Business Media LLC
Reference47 articles.
1. Han, W., Tian, Y. & Shen, X. Human Exposure to Neonicotinoid Insecticides and the Evaluation of Their Potential Toxicity: An Overview. Chemosphere. 192, 59–65 (2018).
2. Brunet, J. L., Badiou, A. & Belzunces, L. P. In Vivo Metabolic Fate of [14C]-Acetamiprid in Six Biological Compartments of the Honeybee, Apis Mellifera L. Pest Manag Sci. 61, 742–748 (2005).
3. Shengyun, S., Xiaoming, L., Renfeng, W. & Yong, W. Efficacy of Several Insecticides on the Control of Myzus Persicae and Lipaphis Erysimi. Pesticide Science and Administration [accessed: 10 March 2019], http://en.cnki.com.cn/Article_en/CJFDTotal-NYKG200507004.htm (2005).
4. Zhou, Q., Ding, Y. & Xiao, J. Sensitive Determination of Thiamethoxam, Imidacloprid and Acetamiprid in Environmental Water Samples with Solid-Phase Extraction Packed with Multiwalled Carbon Nanotubes Prior to High-Performance Liquid Chromatography. Anal Bioanal Chem. 385, 1520–1525 (2006).
5. Goulson, D. An Overview of the Environmental Risks Posed by Neonicotinoid Insecticides. J Appl Ecol. 50, 977–987 (2013).
Cited by
39 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献