Genome-wide association analysis of hypertension and epigenetic aging reveals shared genetic architecture and identifies novel risk loci
Author:
Funder
the Science and Technology Planning Project of Guangzhou
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41598-024-68751-7.pdf
Reference51 articles.
1. Wang, X. M., Wang, H. P., Chen, H. Z. & Liu, D. P. Epigenetic clock: Future of hypertension prediction?. Hypertension 80, 1569–1571. https://doi.org/10.1161/HYPERTENSIONAHA.123.21197 (2023).
2. Timmers, P., Wilson, J. F., Joshi, P. K. & Deelen, J. Multivariate genomic scan implicates novel loci and haem metabolism in human ageing. Nat. Commun. 11, 3570. https://doi.org/10.1038/s41467-020-17312-3 (2020).
3. Kresovich, J. K., Sandler, D. P. & Taylor, J. A. Methylation-based biological age and hypertension prevalence and incidence. Hypertension 80, 1213–1222. https://doi.org/10.1161/HYPERTENSIONAHA.122.20796 (2023).
4. Horvath, S. & Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat. Rev. Genet. 19, 371–384. https://doi.org/10.1038/s41576-018-0004-3 (2018).
5. Rosoff, D. B. et al. Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging. Nat. Aging 3, 1020–1035. https://doi.org/10.1038/s43587-023-00455-5 (2023).
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