A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit-Reference-Cited by-同舟云学术

A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit

Published:2017-10-23 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Kopinja Johnny,Sevilla Raquel S.,Levitan Diane,Dai David,Vanko Amy,Spooner Edward,Ware Chris,Forget Robert,Hu Kun,Kral Astrid,Spacciapoli Peter,Kennan Richard,Jayaraman Lata,Pucci Vincenzo,Perera Samanthi,Zhang Weisheng,Fischer Christian,Lam Michael H.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-14065-w.pdf

Reference23 articles.

1. Balss, J. et al. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol. 116, 597–602 (2008).

2. Cairns, R. A. & Mak, T. W. Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov. 3, 730–741 (2013).

3. Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807–1812 (2008).

4. Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765–773 (2009).

5. Verhaak, R. G. et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17, 98–110 (2010).

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Biostructural, biochemical and biophysical studies of mutant IDH1;Nature Communications;2024-09-09

2. Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study;European Journal of Medicinal Chemistry;2024-09

3. Process Development of a Tricyclic Diazepine-Based IDH1 Mutant Inhibitor;Organic Process Research & Development;2024-06-06

4. IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma;Biological Research;2024-05-17

5. Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors;Biochimica et Biophysica Acta (BBA) - Reviews on Cancer;2024-05