Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα-Reference-Cited by-同舟云学术

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Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

Published:2001-10 Issue:10 Volume:7 Page:1133-1137
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Tuttle Robyn L.,Gill Navdeep S.,Pugh William,Lee Jean-Pyo,Koeberlein Brigitte,Furth Emma E.,Polonsky Kenneth S.,Naji Ali,Birnbaum Morris J.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm1001-1133.pdf

Reference30 articles.

1. Mauricio, D. & Mandrup-Poulsen, T. Apoptosis and the pathogenesis of IDDM: A question of life and death. Diabetes 47, 1537–1543 (1998).

2. Pick, A. et al. Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat. Diabetes 47, 358–364 (1998).

3. Kulkarni, R.N. et al. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329–339 (1999).

4. Withers, D.J. et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900–904 (1998).

5. Coffer, P.J., Jin, J. & Woodgett, J.R. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335, 1–13 (1998).

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