The immunobiology and clinical use of genetically engineered porcine hearts for cardiac xenotransplantation

Author:

Goerlich Corbin E.ORCID,Singh Avneesh K.ORCID,Griffith Bartley P.,Mohiuddin Muhammad M.ORCID

Funder

United Therapeutics Corporation

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Publisher

Springer Science and Business Media LLC

Reference141 articles.

1. Rabin, R. C. In a first, man receives a heart from a genetically altered pig. The New York Times (10 January 2022).

2. Griffith, B. P. et al. Modified pig-to-human cardiac xenotransplantation. N. Engl. J. Med. 387, 35–44 (2022). This sentinel paper highlights the results of an FDA-approved implantation of a genetically modified pig heart into a patient under compassionate use authorization.

3. Taylor, C. J. et al. Trends in survival after a diagnosis of heart failure in the United Kingdom 2000–2017: population based cohort study. Brit. Med. J. 364, l223 (2019).

4. Bui, A. L., Horwich, T. B. & Fonarow, G. C. Epidemiology and risk profile of heart failure. Nat. Rev. Cardiol. 8, 30–41 (2011).

5. Hardy, J. D. et al. Heart transplantation in man. developmental studies and report of a case. J. Am. Med. Asosc. 188, 1132–1140 (1964). The report of the first heart transplantation, which highlights many modern-day issues in transplantation that ring true today, including cardiac preservation, and donor selection owing to supply limitations and ethics.

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