Clonal hematopoiesis in cardiovascular disease and therapeutic implications
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Springer Science and Business Media LLC
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https://www.nature.com/articles/s44161-021-00015-3.pdf
Reference106 articles.
1. Marnell, C. S., Bick, A. & Natarajan, P. Clonal hematopoiesis of indeterminate potential (CHIP): linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease. J. Mol. Cellular Cardiol. 161, 98–105 (2021).
2. Steensma, D. P. et al. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood 126, 9–16 (2015).
3. Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488–2498 (2014). These authors discovered that people with clonal hematopoiesis were at increased risk of developing both hamatological malignancies and atherosclerotic cardiovascular disease.
4. Yu, B. et al. Supplemental association of clonal hematopoiesis with incident heart failure. J. Am. Coll. Cardiol. 78, 42–52 (2021). In a meta-analysis of different studies some, but not all, CHIP variants were found to be associated with an increased incidence of heart failure.
5. Pascual-Figal, D. A. et al. Clonal hematopoiesis and risk of progression of heart failure with reduced left ventricular ejection fraction. J. Am. Coll. Cardiol. 77, 1747–1759 (2021).
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