Current and future strategies for targeting the endothelin pathway in cardiovascular disease
Author:
Funder
DH | National Institute for Health Research
British Heart Foundation
Jon Moulton Charity Trust
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s44161-023-00347-2.pdf
Reference149 articles.
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2. Dhaun, N. & Webb, D. J. Endothelins in cardiovascular biology and therapeutics. Nat. Rev. Cardiol. 16, 491–502 (2019).
3. Endo, H. et al. Effects of clazosentan on cerebral vasospasm–related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage: two randomized phase 3 trials in Japanese patients. J. Neurosurg. 137, 1707–1717 (2022).
4. Schlaich, M. P. et al. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial. Lancet 400, 1927–1937 (2022).
5. Trachtman, H. et al. DUET: a phase 2 study evaluating the efficacy and safety of sparsentan in patients with FSGS. J. Am. Soc. Nephrol. 29, 2745–2754 (2018).
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