Complex disease: Pleiotropic gene effects in obesity and type 2 diabetes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics
Link
http://www.nature.com/articles/5201514.pdf
Reference14 articles.
1. Mitchell BD, Kammerer CM, Mahaney MC et al: Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler Thromb Vasc Biol 1996; 16: 281–288.
2. Meyre D, Bouatia-Naji N, Tounian A et al: Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005; 37: 863–867.
3. Steppan CM, Bailey ST, Bhat S et al: The hormone resistin links obesity to diabetes. Nature 2001; 409: 307–312.
4. Atwood LD, Heard-Costa NL, Cupples LA et al: Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am J Hum Genet 2002; 71: 1044–1050.
5. Duggirala R, Blangero J, Almasy L et al: A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. Am J Hum Genet 2001; 68: 1149–1164.
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