Enriched environments, experience-dependent plasticity and disorders of the nervous system
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn1970.pdf
Reference182 articles.
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2. van Dellen, A., Blakemore, C., Deacon, R., York, D. & Hannan, A. J. Delaying the onset of Huntington's in mice. Nature 404, 721–722 (2000). The first evidence that environmental enrichment can delay the onset of disease symptoms in a genetic model of a nervous system disorder.
3. Hockly, E. et al. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice. Ann. Neurol. 51, 235–242 (2002).
4. Spires, T. L. et al. Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. J. Neurosci. 24, 2270–2276 (2004). Showed that HD-induced downregulation of BDNF and DARPP-32 protein levels is ameliorated by enrichment, suggesting potential therapeutic targets.
5. Arendash, G. W. et al. Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable β-amyloid deposition. Neuroreport 15, 1751–1754 (2004).
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