Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy-Reference-Cited by-同舟云学术

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Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

Published:2009-11 Issue:11 Volume:15 Page:1298-1306
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Geraldes Pedro,Hiraoka-Yamamoto Junko,Matsumoto Motonobu,Clermont Allen,Leitges Michael,Marette Andre,Aiello Lloyd P,Kern Timothy S,King George L

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.2052.pdf

Reference44 articles.

1. Lorenzi, M. & Gerhardinger, C. Early cellular and molecular changes induced by diabetes in the retina. Diabetologia 44, 791–804 (2001).

2. Isermann, B. et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat. Med. 13, 1349–1358 (2007).

3. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977–986 (1993).

4. Mizutani, M., Kern, T.S. & Lorenzi, M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J. Clin. Invest. 97, 2883–2890 (1996).

5. Busik, J.V., Mohr, S. & Grant, M.B. Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes 57, 1952–1965 (2008).

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