Thymic epithelial cell heterogeneity: TEC by TEC
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/s41577-019-0238-0.pdf
Reference128 articles.
1. Klein, L., Kyewski, B., Allen, P. M. & Hogquist, K. A. Positive and negative selection of the T cell repertoire: what thymocytes see (and don’t see). Nat. Rev. Immunol. 14, 377–391 (2014).
2. Aschenbrenner, K. et al. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat. Immunol. 8, 351–358 (2007). This paper presents one of the first key pieces of evidence to show that AIRE + mTECs are not only involved in clonal deletion but also have a key role in the induction of FOXP3 + T reg cells specific for tissue-restricted antigens.
3. Cowan, J. E. et al. The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development. J. Exp. Med. 210, 675–681 (2013).
4. Takahama, Y., Ohigashi, I., Baik, S. & Anderson, G. Generation of diversity in thymic epithelial cells. Nat. Rev. Immunol. 17, 295–305 (2017).
5. Bornstein, C. et al. Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells. Nature 559, 622–626 (2018). This study provides the first comprehensive cell atlas for the thymic stroma (based on scRNA-seq analysis) and identifies thymic tuft cells as a highly divergent subset of mTECs.
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