Metabolic coordination of T cell quiescence and activation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/s41577-019-0203-y.pdf
Reference200 articles.
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3. Tan, H. et al. Integrative proteomics and phosphoproteomics profiling reveals dynamic signaling networks and bioenergetics pathways underlying T cell activation. Immunity 46, 488–503 (2017). This study shows that mTORC1 remodels mitochondrial metabolism and glycolysis through regulation of the T cell proteome and phosphoproteome.
4. Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871–882 (2011). This study establishes MYC-dependent regulation of glycolysis and glutaminolysis as being crucial for T cell activation and proliferation.
5. Yang, K. et al. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity 39, 1043–1056 (2013). This study shows that mTORC1 is a master regulator of T cell quiescence exit, by promoting the six hallmarks of quiescence exit.
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