Lactate modulation of immune responses in inflammatory versus tumour microenvironments
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
https://www.nature.com/articles/s41577-020-0406-2.pdf
Reference130 articles.
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5. Pucino, V. et al. Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4+ T cell metabolic rewiring. Cell Metab. 30, 1055–1074.e8 (2019). This study shows how SLC5A12-driven lactate uptake leads to a stepwise reprogramming of cellular metabolism, which supports a pro-inflammatory response by CD4+ T cells.
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