The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study
Author:
Lloyd PhilippaORCID, Westcott Mark, Kaliki Swathi, Ji Xunda, Zou Yihua, Rashid Riffat, Sultana Sadia, Sherief Sadik Taju, Cassoux Nathalie, Diaz Coronado Rosdali Yesenia, Garcia Leon Juan Luis, López Arturo Manuel Zapata, Polyakov Vladimir G., Ushakova Tatiana L., Roy Soma Rani, Ahmad Alia, Harby Lamis Al, Berry Jesse L., Kim Jonathan, Polski Ashley, Astbury Nicholas J., Bascaran CovadongaORCID, Blum Sharon, Bowman Richard, Burton Matthew J., Foster Allen, Gomel Nir, Keren-Froim Naama, Madgar Shiran, Stacey Andrew W., Mohamed AshikORCID, Zondervan Marcia, Sagoo Mandeep S., Fabian Ido Didi, Reddy M. Ashwin
Abstract
Abstract
Background/Objectives
Retinoblastoma is a common childhood intraocular malignancy, the bilateral form of which most commonly results from a de novo germline pathogenic variant in the RB1 gene. Both advanced maternal age and decreasing birth order are known to increase the risk of de novo germline pathogenic variants, while the influence of national wealth is understudied. This cohort study aimed to retrospectively observe whether these factors influence the ratio of bilateral retinoblastoma cases compared to unilateral retinoblastoma, thereby inferring an influence on the development of de novo germline pathogenic variants in RB1.
Subjects/Methods
Data from 688 patients from 11 centres in 10 countries were analysed using a series of statistical methods.
Results
No associations were found between advanced maternal age, birth order or GDP per capita and the ratio of bilateral to unilateral retinoblastoma cases (p values = 0.534, 0.201, 0.067, respectively), indicating that these factors do not contribute to the development of a de novo pathogenic variant.
Conclusions
Despite a lack of a definitive control group and genetic testing, this study demonstrates that advanced maternal age, birth order or GDP per capita do not influence the risk of developing a bilateral retinoblastoma.
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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1. Global retinoblastoma studies: A review;Clinical & Experimental Ophthalmology;2024-01-23 2. Long non-coding RNAs involved in retinoblastoma;Journal of Cancer Research and Clinical Oncology;2022-10-28
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