Basic-science observations explain how outer retinal hyperreflective foci predict drusen regression and geographic atrophy in age-related macular degeneration
Author:
Funder
Barbara Dunn, Dee and Dickson Brown, Kellogg Eye Center Pre-Residency Fellowship
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology
Link
https://www.nature.com/articles/s41433-021-01748-y.pdf
Reference17 articles.
1. Christenbury JG, Folgar FA, O’Connell RV, Chiu SJ, Farsiu S, Toth CA. Progression of intermediate age-related macular degeneration with proliferation and inner retinal migration of hyperreflective foci. Ophthalmology. 2013;120:1038–45. https://doi.org/10.1016/j.ophtha.2012.10.018.
2. Fleckenstein M, Charbel Issa P, Helb H-M, Schmitz-Valckenberg S, Finger RP, Scholl HP, et al. High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:4137–44. https://doi.org/10.1167/iovs.08-1967.
3. Ouyang Y, Heussen FM, Hariri A, Keane PA, Sadda SR. Optical coherence tomography-based observation of the natural history of drusenoid lesion in eyes with dry age-related macular degeneration. Ophthalmology. 2013;120:2656–65. https://doi.org/10.1016/j.ophtha.2013.05.029.
4. Sleiman K, Veerappan M, Winter KP, McCall MN, Yiu G, Farsiu S, et al. Optical coherence tomography predictors of risk for progression to non-neovascular atrophic age-related macular degeneration. Ophthalmology. 2017;124:1764–77. https://doi.org/10.1016/j.ophtha.2017.06.032.
5. Nassisi M, Fan W, Shi Y, Lei J, Borrelli E, Ip M, et al. Quantity of intraretinal hyperreflective foci in patients with intermediate age-related macular degeneration correlates with 1-year progression. Invest Ophthalmol Vis Sci. 2018;59:3431–9. https://doi.org/10.1167/iovs.18-24143.
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