Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020
Author:
, Furtado João M., Jonas Jost B., Tapply Ian, Fernandes Arthur G., Cicinelli Maria Vittoria, Arrigo Alessandro, Leveziel Nicolas, Resnikoff Serge, Taylor Hugh R., Sedighi Tabassom, Flaxman Seth, Battaglia Parodi Maurizio, Bikbov Mukkharram M., Braithwaite Tasanee, Bron Alain, Cheng Ching-Yu, Congdon Nathan, Del Monte Monte A., Ehrlich Joshua R., Fricke Tim, Friedman David, Gazzard Gus, Hartnett M. Elizabeth, Kahloun Rim, Kempen John H., Khairallah Moncef, Khanna Rohit C., Kim Judy E., Lansingh Van Charles, Leasher Janet, Naidoo Kovin S., Nangia Vinay, Nowak Michal, Pesudovs Konrad, Peto Tunde, Ramulu Pradeep, Topouzis Fotis, Tsilimbaris Mitiadis, Wang Ya Xing, Wang Ningli, Bourne Rupert R. A., Furtado João M.ORCID, Jonas Jost B., Fernandes Arthur G., Cicinelli Maria Vittoria, Leveziel Nicolas, Briant Paul Svitil, Vos Theo, Resnikoff Serge, Fischer Florian, Abate Yohannes Habtegiorgis, Abdollahi Mohammad, Adal Tadele Girum Girum, Addo Isaac Yeboah, Adhikari Kishor, Agarwal Prerna, Agodi Antonella, Agyemang-Duah Williams, Ahmad Aqeel, Ahmadieh Hamid, Ahmadzadeh Hooman, Alahdab Fares, Alfaar Ahmad Samir, Alhassan Robert Kaba, Ali Syed Shujait Shujait, Almidani Louay, Androudi Sofia, Anil Abhishek, Anyasodor Anayochukwu Edward, Arabloo Jalal, Ashemo Mubarek Yesse, Athari Seyyed Shamsadin, Atnafu Desta Debalkie, Atreya Alok, Ayalew Melese Kitu, Aynalem Yared Asmare, Aynalem Zewdu Bishaw, Azzam Ahmed Y., Bagherieh Sara, Bai Ruhai, Barchitta Martina, Bardhan Mainak, Bärnighausen Till Winfried, Bayileyegn Nebiyou Simegnew, Bazvand Fatemeh, Begde Ahmet, Behnam Babak, Bhagavathula Akshaya Srikanth, Bhaskar Sonu, Bhatti Gurjit Kaur, Bhatti Jasvinder Singh, Bintoro Bagas Suryo, Birck Marina G., Braithwaite Tasanee, Burkart Katrin, Bustanji Yasser, Caetano dos Santos Florentino L., Carneiro Vera L. A., Cenderadewi Muthia, Chattu Vijay Kumar, Chu Dinh-Toi, Coberly Kaleb, Cruz-Martins Natália, Dadras Omid, Dai Xiaochen, Dascalu Ana Maria, Dashti Mohsen, Dastiridou Anna, Dastmardi Maedeh, Deng Xinlei, Dervenis Nikolaos, Devanbu Vinoth Gnana Chellaiyan, Diress Mengistie, Djalalinia Shirin, Ehrlich Joshua R., Ekholuenetale Michael, Ekundayo Temitope Cyrus, El Sayed Iman, Elhadi Muhammed, Emamverdi Mehdi, Emrie Ambaw Abebaw, Fagbamigbe Adeniyi Francis, Fahim Ayesha, Farooq Umar, Farrokhpour Hossein, Fatehizadeh Ali, Feizkhah Alireza, Ferro Desideri Lorenzo, Fetensa Getahun, Feyisa Bikila Regassa, Flaxman Seth, Forouhari Ali, Foschi Matteo, Fowobaje Kayode Raphael, Gandhi Aravind P., Gebi Tilaye Gebru, Gebregergis Miglas W., Gebrehiwot Mesfin, Gebremariam Brhane, Gebremeskel Gebreamlak Gebremedhn, Gela Yibeltal Yismaw, Gesese Molalegn Mesele, Ghasemi Falavarjani Khalil, Ghassemi Fariba, Ghozy Sherief, Golechha Mahaveer, Goleij Pouya, Gupta Sapna, Gupta Veer Bala, Gupta Vivek Kumar, Haile Teklehaimanot Gereziher, Hailu Semira Goitom, Haj-Mirzaian Arvin, Halimi Aram, Hallaj Shahin, Hammond Billy Randall, Hasan Ikramul, Hasani Hamidreza, Hassanian-Moghaddam Hossein, Heidari-Foroozan Mahsa, Hong Sung Hwi, Hoogar Praveen, Hosseinzadeh Mehdi, Hu Chengxi, Huynh Hong-Han, Immurana Mustapha, Iwu Chidozie C. D., Jacob Louis, Jafarzadeh Abdollah, Jakovljevic Mihajlo, Jayaram Shubha, Jokar Mohammad, Joseph Nitin, Joshua Charity Ehimwenma, Kabito Gebisa Guyasa, Kalankesh Laleh R., Kamath Sagarika, Kandel Himal, Karaye Ibraheem M., Kasraei Hengameh, Kayode Gbenga A., Kedir Shemsu, Khader Yousef Saleh, Khajuria Himanshu, Khatatbeh Moawiah Mohammad, Khatib Mahalaqua Nazli, Khorrami Zahra, Kim Yun Jin, Kisa Adnan, Kisa Sezer, Kosen Soewarta, Koyanagi Ai, Krishan Kewal, Lahariya Chandrakant, Laksono Tri, Lal Dharmesh Kumar, Lansingh Van Charles, Le Trang D. T., Leasher Janet L., Lee Munjae, Lee Seung Won, Lee Wei-Chen, Lim Stephen S., Liu Xuefeng, Mahmoudi Alireza, Mahmoudi Razzagh, Malhotra Kashish, Mansouri Vahid, Marzo Roy Rillera, Maugeri Andrea, McAlinden Colm, Mekene Meto Tesfahun, Mersha Abera M., Mestrovic Tomislav, Mihretie Ephrem Tesfaye, Mirzaei Mehdi, Mithra Prasanna, Mohamed Nouh Saad, Mohammadi Soheil, Mohammed Abdulwase, Mokdad Ali H., Molavi Vardanjani Hossein, Moni Mohammad Ali, Montazeri Fateme, Moradi Maryam, Mousavi Parsa, Muhamed Ahmed Nuru, Mulita Admir, Naidoo Kovin S., Naik Ganesh R., Nargus Shumaila, Natto Zuhair S., Nayak Biswa Prakash, Negaresh Mohammad, Negash Hadush, Nejadghaderi Seyed Aria, Nguyen Dang H., Nguyen Hien Quang, Nguyen Phat Tuan, Nguyen Van Thanh, Niazi Robina Khan, Noreen Mamoona, Nzoputam Ogochukwu Janet, Odetokun Ismail A., Olagunju Andrew T., Olatubi Matthew Idowu, Onwujekwe Obinna E., Ordak Michal, Osuagwu Uchechukwu Levi, Otstavnov Nikita, Owolabi Mayowa O., Padubidri Jagadish Rao, Panahi Parsa, Pandey Ashok, Pardhan Shahina, Patel Jay, Patthipati Venkata Suresh, Pawar Shrikant, Perianayagam Arokiasamy, Petcu Ionela-Roxana, Pham Hoang Tran, Qattea Ibrahim, Raghav Pankaja Raghav, Rahim Fakher, Rahimi-Movaghar Vafa, Rahman Mohammad Hifz Ur, Rahman Mosiur, Ramasubramani Premkumar, Rashid Ahmed Mustafa, Rauf Annisa Utami, Redwan Elrashdy Moustafa Mohamed, Rezaei Nazila, Roy Priyanka, Saadatian Zahra, Sabour Siamak, Saddik Basema, Saeed Umar, Safi Sare, Safi Sher Zaman, Saghazadeh Amene, Saheb Sharif-Askari Fatemeh, Saheb Sharif-Askari Narjes, Sahebkar Amirhossein, Sakshaug Joseph W., Salahi Saina, Salahi Sarvenaz, Saleh Mohamed A., Samodra Yoseph Leonardo, Samuel Vijaya Paul, Samy Abdallah M., Saravanan Aswini, Sawhney Monika, Saylan Mete, Sediqi Sayed Mansoor, Selvaraj Siddharthan, Sethi Yashendra, Seylani Allen, Shah Jaffer, Shahid Samiah, Shahwan Moyad Jamal, Shaikh Masood Ali, Shamim Muhammad Aaqib, Shayan Maryam, Shigematsu Mika, Shittu Aminu, Shorofi Seyed Afshin, Siddig Emmanuel Edwar, Silva Juan Carlos, Singh Jasvinder A., Singh Paramdeep, Skiadaresi Eirini, Sousa Raúl A. R. C., Sreeramareddy Chandrashekhar T., Starodubov Vladimir I., Taye Birhan Tsegaw, Ticoalu Jansje Henny Vera, Tsegay Guesh Mebrahtom, Tsilimbaris Miltiadis K., Ullah Saif, Umair Muhammad, Valadan Tahbaz Sahel, Wickramasinghe Nuwan Darshana, Wondimagegn Guadie Sharew, Yang Lin, Yiğit Arzu, Yon Dong Keon, Yonemoto Naohiro, You Yuyi, Zastrozhin Mikhail Sergeevich, Zhao Hanqing, Zheng Peng, Ziafati Makan, Zielińska Magdalena, Steinmetz Jaimie D., Bourne Rupert R. A.ORCID,
Abstract
Abstract
Background
We aimed to update estimates of global vision loss due to age-related macular degeneration (AMD).
Methods
We did a systematic review and meta-analysis of population-based surveys of eye diseases from January, 1980, to October, 2018. We fitted hierarchical models to estimate the prevalence of moderate and severe vision impairment (MSVI; presenting visual acuity from <6/18 to 3/60) and blindness ( < 3/60) caused by AMD, stratified by age, region, and year.
Results
In 2020, 1.85 million (95%UI: 1.35 to 2.43 million) people were estimated to be blind due to AMD, and another 6.23 million (95%UI: 5.04 to 7.58) with MSVI globally. High-income countries had the highest number of individuals with AMD-related blindness (0.60 million people; 0.46 to 0.77). The crude prevalence of AMD-related blindness in 2020 (among those aged ≥ 50 years) was 0.10% (0.07 to 0.12) globally, and the region with the highest prevalence of AMD-related blindness was North Africa/Middle East (0.22%; 0.16 to 0.30). Age-standardized prevalence (using the GBD 2019 data) of AMD-related MSVI in people aged ≥ 50 years in 2020 was 0.34% (0.27 to 0.41) globally, and the region with the highest prevalence of AMD-related MSVI was also North Africa/Middle East (0.55%; 0.44 to 0.68). From 2000 to 2020, the estimated crude prevalence of AMD-related blindness decreased globally by 19.29%, while the prevalence of MSVI increased by 10.08%.
Conclusions
The estimated increase in the number of individuals with AMD-related blindness and MSVI globally urges the creation of novel treatment modalities and the expansion of rehabilitation services.
Publisher
Springer Science and Business Media LLC
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