Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus-Reference-Cited by-同舟云学术

Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus

Published:2016-08 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Scorsato Valéria,Lima Tatiani B.,Righetto Germanna L.,Zanchin Nilson I. T.,Brandão-Neto José,Sandy James,Pereira Humberto D’Muniz,Ferrari Állan J. R.,Gozzo Fabio C.,Smetana Juliana H. C.,Aparicio Ricardo

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep30813.pdf

Reference45 articles.

1. Bryant, J. C., Westphal, R. S. & Wadzinski, B. E. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. Biochemical Journal 339, 241 (1999).

2. Yu, X. X. et al. Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol. Biol. Cell 12, 185–199 (2001).

3. Lee, J. & Lee, D.-H. Leucine methylation of protein phosphatase PP4C at C-terminal is critical for its cellular functions. Biochem. Biophys. Res. Commun. 452, 42–47 (2014).

4. Sents, W., Ivanova, E., Lambrecht, C., Haesen, D. & Janssens, V. The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity. FEBS J. 280, 644–661 (2012).

5. Sangodkar, J. et al. All roads lead to PP2A: Exploiting the therapeutic potential of this phosphatase. FEBS J (2015)

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. TIPRL, a Potential Double-edge Molecule to be Targeted and Re-targeted Toward Cancer;Cell Biochemistry and Biophysics;2024-06-18

2. TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer;Cellular Oncology;2023-11-16

3. TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer;2023-09-04

4. Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules;Journal of Biological Chemistry;2022-12

5. Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development;Frontiers in Genetics;2022-09-23