An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation-Reference-Cited by-同舟云学术

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An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

Published:2011-08-07 Issue:9 Volume:18 Page:999-1005
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Lyon Angeline M,Tesmer Valerie M,Dhamsania Vishan D,Thal David M,Gutierrez Joanne,Chowdhury Shoaib,Suddala Krishna C,Northup John K,Tesmer John J G

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.2095.pdf

Reference53 articles.

1. Rhee, S.G. Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem. 70, 281–312 (2001).

2. Rebecchi, M.J. & Pentyala, S.N. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80, 1291–1335 (2000).

3. Taylor, S.J. & Exton, J.H. Two a subunits of the Gq class of G proteins stimulate phosphoinositide phospholipase C-β1 activity. FEBS Lett. 286, 214–216 (1991).

4. Smrcka, A.V., Hepler, J.R., Brown, K.O. & Sternweis, P.C. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq . Science 251, 804–807 (1991).

5. Park, D., Jhon, D.Y., Lee, C.W., Lee, K.H. & Rhee, S.G. Activation of phospholipase C isozymes by G protein βγ subunits. J. Biol. Chem. 268, 4573–4576 (1993).

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