Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial

Author:

Fehlings M G,Nakashima H,Nagoshi N,Chow D S L,Grossman R G,Kopjar B

Publisher

Springer Science and Business Media LLC

Subject

Clinical Neurology,Neurology,General Medicine

Reference20 articles.

1. Sekhon LH, Fehlings MG . Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine 2001; 26: S2–S12.

2. Baptiste DC, Fehlings MG . Pharmacological approaches to repair the injured spinal cord. J Neurotrauma 2006; 23: 318–334.

3. Miller RG, Mitchell J, Moore DH . Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev 2012; 3: CD001447.

4. Schwartz G, Fehlings MG . Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole. J Neurosurg 2001; 94: 245–256.

5. Wu Y, Satkunendrarajah K, Teng Y, DS-L Chow, Buttigieg J, Fehlings MG . Delayed post-injury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury. J Neurotrauma 2013; 30: 441–452.

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