Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site-Reference-Cited by-同舟云学术

Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site

Published:2014-01-06 Issue:1 Volume:5 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Chen Wen,Gamache Eric,Rosenman David J.,Xie Jian,Lopez Maria M.,Li Yue-Ming,Wang Chunyu

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms4037.pdf

Reference45 articles.

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4. Burdick, D. et al. Assembly and aggregation properties of synthetic Alzheimer’s A4/beta amyloid peptide analogs. J. Biol. Chem. 267, 546–554 (1992).

5. Zhang, Y., McLaughlin, R., Goodyer, C. & LeBlanc, A. Selective cytotoxicity of intracellular amyloid beta peptide(1-42) through p53 and Bax in cultured primary human neurons. J. Cell Biol. 156, 519–529 (2002).

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