Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

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Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia

Published:2003-12-02 Issue:1 Volume:4 Page:66-72
ISSN:1470-269X
Container-title:The Pharmacogenomics Journal
language:en
Short-container-title:Pharmacogenomics J

Author:

Krajinovic M,Lemieux-Blanchard É,Chiasson S,Primeau M,Costea I,Moghrabi A

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Genetics,Molecular Medicine

Link

http://www.nature.com/articles/6500224.pdf

Reference43 articles.

1. Shane B . Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism. Vitam Horm 1989; 45: 263–335.

2. Schwahn B, Rozen R . Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. Am J Pharmacogenomics 2001; 1: 189–201.

3. Hum DW, Bell AW, Rozen R, MacKenzie RE . Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase–methenyltetrahydrofolate cyclohydrolase–formyltetrahydrofolate synthetase. J Biol Chem 1988; 263: 15946–15950.

4. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111–113.

5. Weisberg I, Tran P, Christensen B, Sibani S, Rozen R . A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 1998; 64: 169–172.

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