The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels

Author:

Kerb R,Aynacioglu A S,Brockmöller J,Schlagenhaufer R,Bauer S,Szekeres T,Hamwi A,Fritzer-Szekeres M,Baumgartner C,Öngen H Z,Güzelbey P,Roots I,Brinkmann U

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Genetics,Molecular Medicine

Reference31 articles.

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2. Yasumori T, Chen LS, Li QH, Ueda M, Tsuzuki T, Goldstein JA et al. Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19 Biochem Pharmacol 1999 57: 1297–1303

3. Veronese ME, Doecke CJ, Mackenzie PI, McManus ME, Miners JO, Rees DL et al. Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily Biochem J 1993 289: 533–538

4. De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA . Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese Mol Pharmacol 1994 46: 594–598

5. De Morais SM, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA, Goldstein JA . The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans J Biol Chem 1994 269: 15419–15422

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