CYP2C9*3 influences the metabolism and the drug-interaction of candesartan in vitro

Author:

Hanatani T,Fukuda T,Ikeda M,Imaoka S,Hiroi T,Funae Y,Azuma J

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Genetics,Molecular Medicine

Reference22 articles.

1. Shibouta Y, Inada Y, Ojima M, Wada T, Noda M, Sanada T et al. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2′-(1H-ttrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11874), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116) J Pharm Exp Ther 1993 266: 114–120

2. McClellan KJ, Goa KL . Candesartan cilexetil Drugs 1998 56: 847–869

3. Miners JO, Birkett DJ . Cytochrome P4502C9: an enzyme of major importance in human metabolism Br J Clin Pharmacol 1998 45: 525–538

4. Wang Sl, Huang J, Lai MD, Tsai JJ . Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese Pharmacogenetics 1995 5: 37–42

5. Nasu K, Kubota T, Ishizaki T . Genetic analysis of CYP2C9 polymorphism in a Japanese population Pharmacogenetics 1997 7: 405–449

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