Drug discovery with engineered zinc-finger proteins
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1087.pdf
Reference74 articles.
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2. Miller, J., McLachlan, A. D. & Klug, A. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 4, 1609–1614 (1985).
3. Berg, J. M. Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins. Proc. Natl Acad. Sci. USA 85, 99–102 (1988).
4. Lee, M. S. et al. Three-dimensional solution structure of a single zinc finger DNA-binding domain. Science 245, 635–637 (1989).
5. Pavletich, N. P. & Pabo, C. O. Zinc finger-DNA recognition: crystal structure of a Zif268–DNA complex at 2. 1 A. Science 252, 809–817 (1991). The first crystal structure to give a detailed view of how ZFPs recognize DNA. This paper laid the foundation for the subsequent experiments in zinc finger protein engineering.
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