Modulation of the intracellular inhibitory checkpoint SHP-1 enhances the antitumor activity of engineered NK cells-Reference-Cited by-同舟云学术

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Modulation of the intracellular inhibitory checkpoint SHP-1 enhances the antitumor activity of engineered NK cells

Published:2020-04-27 Issue:5 Volume:18 Page:1314-1316
ISSN:1672-7681
Container-title:Cellular & Molecular Immunology
language:en
Short-container-title:Cell Mol Immunol

Author:

Ben-Shmuel Aviad,Biber Guy,Sabag Batel,Barda-Saad Mira

Funder

Israel Science Foundation

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Immunology,Immunology and Allergy

Link

http://www.nature.com/articles/s41423-020-0443-6.pdf

Reference10 articles.

1. Vivier, E., Tomasello, E., Baratin, M., Walzer, T. & Ugolini, S. Functions of natural killer cells. Nat. Immunol. 9, 503–510 (2008).

2. Moretta, L. & Moretta, A. Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 23, 255–259 (2004).

3. Stebbins, C. C. et al. Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity. Mol. Cell. Biol. 23, 6291–6299 (2003).

4. Matalon, O. et al. Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity. Sci. Signal. 9, ra54 (2016).

5. Matalon, O. et al. Actin retrograde flow controls natural killer cell response by regulating the conformation state of SHP-1. EMBO J. 37, e96264 (2018).

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