RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Immunology,Immunology and Allergy
Link
http://www.nature.com/articles/s41423-021-00683-y.pdf
Reference58 articles.
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2. Davis, B. K., Wen, H. T. & Ting, J. P. Y. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu. Rev. Immunol. 29 29, 707–735 (2011).
3. Chen, G., Shaw, M. H., Kim, Y. G. & Nunez, G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev. Pathol.-Mech. 4, 365–398 (2009).
4. Broz, P. & Dixit, V. M. Inflammasomes: mechanism of assembly, regulation and signalling. Nat. Rev. Immunol. 16, 407–420 (2016).
5. Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237–241 (2006).
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