Impact of human sequences in variable domains of therapeutic antibodies on the location of CD4 T-cell epitopes
Author:
Funder
Innovative Medicines Initiative
Novartis
Labex LERMIT
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Immunology,Immunology and Allergy
Link
http://www.nature.com/articles/s41423-019-0304-3.pdf
Reference7 articles.
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2. Calabresi, P. A. et al. The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL. Neurology 69, 1391–1403 (2007).
3. Hamze, M. et al. Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors. Front. Immunol. 8, 500 (2017).
4. Harding, F. A., Stickler, M. M., Razo, J. & DuBridge, R. B. The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions. mAbs 2, 256–265 (2010).
5. Detanico, T., Heiser, R. A., Aviszus, K., Bonorino, C. & Wysocki, L. J. Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor. J. Immunol. 187, 82–91 (2011).
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