Author:
Elsayh Khalid Ibrahim,Saad Khaled,Osman Naglaa Samy,Mahmoud Khaled Hashim,Ahmad Faisal A.,Khalaf Shaimaa M.,Sayed Noha G.,Zahran Zeinab Albadry M.,Ghandour Aliaa M. A.,Elhoufey Amira A.,Bedir Tamer,Zahran Asmaa
Abstract
Abstract
Background
Immune thrombocytopenia (ITP) is an acquired autoimmune disease. This study’s objective was to estimate the variations in the population of CD4+CD25+High FoxP3+ cells (CD4+ regulatory T-lymphocytes; Tregs) in previously untreated children with chronic ITP managed in Assiut University Hospitals, as well as to evaluate the efficacy of high-dose dexamethasone (HD-DXM) in these patients.
Methods
In this study, we investigated the frequencies of T-lymphocyte subsets in 27 untreated children with chronic ITP.
Results
Prior to treatment, the percentages of CD4+CD25High cells and Tregs were significantly lower in the chronic ITP group compared to the control group (p = 0.018 and p < 0.0001, respectively). After treatment with HD-DXM, Tregs and platelets were significantly increased in these patients (p < 0.0001 for both).
Conclusions
Our results suggest that Tregs are deficient in children with chronic ITP and that HD-DXM immunosuppressive therapy can restore the levels of these cells.
Impact
CD4+CD25High cells and Tregs were significantly lower in children chronic ITP compared to healthy control.
HD-DXM treatment led to significantly increased Tregs and platelets in these patients.
Our results suggest that Tregs are deficient in children with chronic ITP and that HD-DXM immunosuppressive therapy can restore the levels of these cells.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
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