Consequences of gestational diabetes mellitus on neonatal cardiovascular health: MySweetHeart Cohort study
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Published:2022-11-28
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ISSN:0031-3998
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Container-title:Pediatric Research
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language:en
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Short-container-title:Pediatr Res
Author:
Di Bernardo Stefano C., Lava Sebastiano A. G., Epure Adina Mihaela, Younes Sandrine Estoppey, Chiolero Arnaud, Sekarski NicoleORCID, Arhab Amar, Bovet Pascal, Chiolero Arnaud, Di Bernardo Stefano, Epure Adina Mihaela, Gilbert Leah, Gross Justine, Horsch Antje, Lanzi Stefano, Mayerat Seyda, Mivelaz Yvan, Puder Jardena J., Quansah Dan, Rossel Jean‐Benoit, Simeoni Umberto, Stuijfzand Bobby, Vial Yvan,
Abstract
AbstractBackgroundHyperglycaemic disorders of pregnancy are associated with offspring cardiovascular alterations.MethodsMySweetHeart cohort study aimed to assess the effect of maternal gestational diabetes (GDM) on offsprings’ cardiovascular health. Newborns underwent clinical and echocardiographic examinations between 2016 and 2020.ResultsCompared to mothers without GDM (n = 141), mothers with GDM (n = 123) were more likely to have had GDM in previous pregnancies and had higher weight, BMI, blood glucose, and HbA1c. Newborns of both groups showed similar clinical characteristics. Echocardiography was performed on the 3rd (interquartile range, IQR, 2nd–4th) day of life in 101 offsprings of mothers without and 116 offsprings of mothers with GDM. Left ventricular (LV) mass was similar. Children born to mothers with GDM had a thicker posterior LV wall (z-score +0.15, IQR –0.38/0.62, versus +0.47, IQR –0.11/+1.1,p = 0.004), a smaller end-systolic (1.3 mL, IQR 1.0–1.5 mL, versus 1.4 mL, IQR 1.2–1.8 mL,p = 0.044) but a similar end-diastolic LV volume. They also had shorter tricuspid valve flow duration and aortic valve ejection time, lower tricuspid E-wave and pulmonary valve velocities.ConclusionsNewborns of mothers with or without GDM had similar clinical characteristics and LV mass. However, some echocardiographic differences were detected, suggesting an altered myocardial physiology among infants of mothers with GDM.RegistrationClinicalTrials.gov (NCT02872974).ImpactHyperglycaemic disorders of pregnancy are known to be associated with offspring cardiovascular alterations.Clinical characteristics and estimated left ventricular (LV) mass were similar in children issued from mothers with and without gestational diabetes (GDM).Children born to mothers with GDM had a thicker posterior LV wall and a smaller end-systolic LV volume.Although LV mass is not different, myocardial physiology may be altered in these infants. Further studies should investigate the endothelial function of this population and the cardiovascular evolution of these children over time.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health
Reference31 articles.
1. GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390, 1151–1210 (2017). 2. Charakida, M., Deanfield, J. E. & Halcox, J. P. Childhood origins of arterial disease. Curr. Opin. Pediatr. 19, 538–545 (2007). 3. Barker, D. J., Osmond, C., Golding, J., Kuh, D. & Wadsworth, M. E. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 298, 564–567 (1989). 4. Barker, D. J., Eriksson, J. G., Forsén, T. & Osmond, C. Fetal origins of adult disease: strength of effects and biological basis. Int J. Epidemiol. 31, 1235–1239 (2002). 5. Franks, P. W. et al. Childhood obesity, other cardiovascular risk factors, and premature death. N. Engl. J. Med. 362, 485–493 (2010).
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