TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer-Reference-Cited by-同舟云学术

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

Published:2011-05-31 Issue:1 Volume:2 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Mu Yabing,Sundar Reshma,Thakur Noopur,Ekman Maria,Gudey Shyam Kumar,Yakymovych Mariya,Hermansson Annika,Dimitriou Helen,Bengoechea-Alonso Maria Teresa,Ericsson Johan,Heldin Carl-Henrik,Landström Marene

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms1332.pdf

Reference28 articles.

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2. Massagué, J. TGFbeta in Cancer. Cell 134, 215–230 (2008).

3. Heldin, C.- H., Landstrom, M. & Moustakas, A. Mechanism of TGF-β signaling to growth arrest, apoptosis and epithelial-mesenchymal transition. Curr. Opion in Cell Biology 21, 1–11 (2009).

4. Hayes, S., Chawla, A. & Corvera, S. TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J. Cell Biol. 158, 1239–1249 (2002).

5. Sorrentino, A. et al. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat. Cell Biol. 10, 1199–1207 (2008).

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