Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity-Reference-Cited by-同舟云学术

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Published:2017-01-03 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Soethoudt Marjolein,Grether Uwe,Fingerle Jürgen,Grim Travis W.,Fezza Filomena,de Petrocellis Luciano,Ullmer Christoph,Rothenhäusler Benno,Perret Camille,van Gils Noortje,Finlay David,MacDonald Christa,Chicca Andrea,Gens Marianela Dalghi,Stuart Jordyn,de Vries Henk,Mastrangelo Nicolina,Xia Lizi,Alachouzos Georgios,Baggelaar Marc P.,Martella Andrea,Mock Elliot D.,Deng Hui,Heitman Laura H.,Connor Mark^ORCID,Di Marzo Vincenzo,Gertsch Jürg,Lichtman Aron H.,Maccarrone Mauro^ORCID,Pacher Pal,Glass Michelle,van der Stelt Mario

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms13958.pdf

Reference70 articles.

1. Gashaw, I., Ellinghaus, P., Sommer, A. & Asadullah, K. What makes a good drug target? Drug Discov. Today 16, 1037–1043 (2011).

2. Pacher, P. & Mechoulam, R. Is lipid signaling through cannabinoid 2 receptors part of a protective system? Prog. Lipid Res. 50, 193–211 (2011).

3. Van Der Stelt, M. et al. Discovery and optimization of 1-(4-(Pyridin-2-yl)benzyl)imidazolidine-2,4- dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. J. Med. Chem. 54, 7350–7362 (2011).

4. Guindon, J. & Hohmann, A. G. Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain. Br. J. Pharmacol. 153, 319–334 (2008).

5. Kusakabe, K. et al. Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones. Bioorg. Med. Chem. 21, 3154–3163 (2013).

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