Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors-Reference-Cited by-同舟云学术

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Published:2016-10-11 Issue:1 Volume:7 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Zuhl Andrea M.,Nolan Charles E.,Brodney Michael A.,Niessen Sherry,Atchison Kevin,Houle Christopher,Karanian David A.,Ambroise Claude,Brulet Jeffrey W.,Beck Elizabeth M.,Doran Shawn D.,O’Neill Brian T.,am Ende Christopher W.,Chang Cheng,Geoghegan Kieran F.,West Graham M.,Judkins Joshua C.,Hou Xinjun,Riddell David R.,Johnson Douglas S.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms13042.pdf

Reference56 articles.

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4. Lanning, B. R. et al. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors. Nat. Chem. Biol. 10, 760–767 (2014).

5. Paolini, G. V. et al. Global mapping of pharmacological space. Nat. Biotechnol. 24, 805–815 (2006).

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