Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
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Published:2016-11-29
Issue:1
Volume:7
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Paul Dirk S.ORCID, Teschendorff Andrew E., Dang Mary A.N., Lowe Robert, Hawa Mohammed I., Ecker Simone, Beyan Huriya, Cunningham Stephanie, Fouts Alexandra R., Ramelius Anita, Burden Frances, Farrow Samantha, Rowlston Sophia, Rehnstrom Karola, Frontini MattiaORCID, Downes Kate, Busche Stephan, Cheung Warren A., Ge Bing, Simon Marie-Michelle, Bujold David, Kwan Tony, Bourque Guillaume, Datta Avik, Lowy Ernesto, Clarke LauraORCID, Flicek PaulORCID, Libertini Emanuele, Heath SimonORCID, Gut Marta, Gut Ivo G, Ouwehand Willem H., Pastinen Tomi, Soranzo NicoleORCID, Hofer Sabine E., Karges Beate, Meissner Thomas, Boehm Bernhard O., Cilio Corrado, Elding Larsson Helena, Lernmark Åke, Steck Andrea K., Rakyan Vardhman K., Beck StephanORCID, Leslie R. David
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference72 articles.
1. Bluestone, J. A., Herold, K. & Eisenbarth, G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464, 1293–1300 (2010). 2. Patterson, C. C., Dahlquist, G. G., Gyürüs, E., Green, A. & Soltész, G. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 373, 2027–2033 (2009). 3. Atkinson, M. A., Eisenbarth, G. S. & Michels, A. W. Type 1 diabetes. Lancet 383, 69–82 (2014). 4. Redondo, M. J. et al. Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States. Diabetologia 44, 354–362 (2001). 5. Schübeler, D. Function and information content of DNA methylation. Nature 517, 321–326 (2015).
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