Is there a safe time to discontinue therapy in MS?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Clinical Neurology
Link
http://www.nature.com/articles/nrneurol.2016.192.pdf
Reference7 articles.
1. Freedman, M. S. et al. Moving toward earlier treatment of multiple sclerosis: findings from a decade of clinical trials and implications for clinical practice. Mult. Scler. Relat. Disord. 3, 147–155 (2014).
2. Bsteh, G. et al. Discontinuation of disease-modifying therapies in multiple sclerosis — clinical outcome and prognostic factors. Mult. Scler. http://dx.doi.org/10.1177/1352458516675751 (2016).
3. Tobin, W. O. & Weinshenker, B. G. Stopping immunomodulatory medications in MS: frequency, reasons and consequences. Mult. Scler. Relat. Disord. 4, 437–443 (2015).
4. Kister, I. et al. Discontinuing disease-modifying therapy in MS after a prolonged relapse-free period: a propensity score-matched study. J. Neurol. Neurosurg. Psychiatry 87, 1133–1137 (2016).
5. Vellinga, M. M., Castelijns, J. A., Barkhof, F., Uitdehaag, B. M. & Polman, C. H. Postwithdrawal rebound increase in T2 lesional activity in natalizumab-treated MS patients. Neurology 70, 1150–1151 (2008).
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