How can we improve clinical trials in amyotrophic lateral sclerosis?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Clinical Neurology
Link
http://www.nature.com/articles/nrneurol.2011.147.pdf
Reference61 articles.
1. Swash, M. We have a problem: why have ALS trials been negative? Amyotroph. Lateral Scler. 8, 259 (2007).
2. Swash, M. Lithium time-to-event trial in amyotrophic lateral sclerosis stops early for futility. Lancet Neurol. 9, 449–451 (2010).
3. Aggarwal, S. & Cudkowicz, M. ALS drug development: reflections from the past and a way forward. Neurotherapeutics 5, 516–527 (2008).
4. Ludolph, A. C. et al. Guidelines for preclinical animal research in ALS/MND: a consensus meeting. Amyotroph. Lateral Scler. 11, 38–45 (2010).
5. Mitsumoto, H. et al. Randomized control trials in ALS: lessons learned. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 5 (Suppl. 1), 8–13 (2004).
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