The mTOR signalling cascade: paving new roads to cure neurological disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology (clinical)
Link
http://www.nature.com/articles/nrneurol.2016.81.pdf
Reference163 articles.
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2. Bockaert, J. & Marin, P. mTOR in brain physiology and pathologies. Physiol. Rev. 95, 1157–1187 (2015). A comprehensive review of cellular and molecular biology of mTOR and its contributions to brain function.
3. Crino, P. B. mTOR: a pathogenic signaling pathway in developmental brain malformations. Trends Mol. Med. 17, 734–742 (2011). Review of single-gene mutations in the mTOR pathway that have been associated with brain malformations.
4. LaSarge, C. L. & Danzer, S. C. Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. Front. Mol. Neurosci. 7, 18–24 (2014). A summary of mTOR-mediated regulation of neuronal excitability and the involvement of impaired mTOR regulatory control on seizures and behavioural alterations.
5. Tang, S. J. et al. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc. Natl Acad. Sci. USA 99, 467–472 (2002).
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