APC‐targeted proinsulin expression inactivates insulin‐specific memory CD8 + T cells in NOD mice-Reference-Cited by-同舟云学术

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APC‐targeted proinsulin expression inactivates insulin‐specific memory CD8 + T cells in NOD mice

Published:2017-07-11 Issue:9 Volume:95 Page:765-774
ISSN:0818-9641
Container-title:Immunology & Cell Biology
language:en
Short-container-title:Immunol Cell Biol

Author:

Reeves Peta LS¹,Rudraraju Rajeev¹,Liu Xiao¹,Wong F Susan²,Hamilton‐Williams Emma E¹,Steptoe Raymond J¹

Affiliation:

1. The University of Queensland Diamantina Institute Brisbane Queensland Australia

2. Institute of Molecular & Experimental Medicine, Cardiff University School of Medicine Cardiff Wales

Funder

Australian Research Council

National Health and Medical Research Council

Juvenile Diabetes Research Foundation International

Medical Research Council

Publisher

Wiley

Subject

Cell Biology,Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1038/icb.2017.48

Reference55 articles.

1. Autoantigen-specific memory CD4+ T cells are prevalent early in progression to Type 1 diabetes

2. Intermolecular Antigen Spreading Occurs During the Preclinical Period of Human Type 1 Diabetes

3. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

4. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

5. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

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