A Systematic Approach to Time-series Metabolite Profiling and RNA-seq Analysis of Chinese Hamster Ovary Cell Culture

Author:

Hsu Han-Hsiu,Araki Michihiro,Mochizuki Masao,Hori Yoshimi,Murata Masahiro,Kahar Prihardi,Yoshida Takanobu,Hasunuma Tomohisa,Kondo Akihiko

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference23 articles.

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2. Lewis, A. M., Abu-Absi, N. R., Borys, M. C. & Li, Z. J. The use of “Omics technology to rationally improve industrial mammalian cell line performance. Biotechnol. Bioeng. 113, 26–38 (2016).

3. Schaub, J., Clemens, C., Kaufmann, H. & Schulz, T. W. Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data. Genom. Syst. Biol. Mamm. Cell Cult. 127, 133–163 (2012).

4. Schaub, J. et al. CHO Gene Expression Profiling in Biopharmaceutical Process Analysis and Design. Biotechnol. Bioeng. 105, 431–438 (2010).

5. Hammond, S., Kaplarevic, M., Borth, N., Betenbaugh, M. J. & Lee, K. H. Chinese hamster genome database: An online resource for the CHO community at http://www.CHOgenome.org . Biotechnol. Bioeng. 109, 1353–1356 (2012).

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