Admixture Mapping of Alzheimer’s disease in Caribbean Hispanics identifies a new locus on 22q13.1

Author:

Kizil Caghan,Sariya Sanjeev,Kim Yoon A.,Rajabli Farid,Martin Eden,Reyes-Dumeyer Dolly,Vardarajan Badri,Maldonado Aleyda,Haines Jonathan L.,Mayeux Richard,Jiménez-Velázquez Ivonne Z.,Santa-Maria Ismael,Tosto GiuseppeORCID

Funder

Foundation for the National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Molecular Biology

Reference48 articles.

1. Tang MX, Cross P, Andrews H, Jacobs DM, Small S, Bell K, et al. Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan. Neurology. 2001;56:49–56. https://doi.org/10.1212/wnl.56.1.49. PubMed PMID: 11148235.

2. Vardarajan BN, Faber KM, Bird TD, Bennett DA, Rosenberg R, Boeve BF, et al. Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). JAMA Neurol. 2014;71:315–23. https://doi.org/10.1001/jamaneurol.2013.5570. PubMed PMID: 24425039; PubMed Central PMCID: PMCPMC4000602.

3. Tang MX, Stern Y, Marder K, Bell K, Gurland B, Lantigua R, et al. The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA. 1998;279:751–5. https://doi.org/10.1001/jama.279.10.751. PubMed PMID: 9508150.

4. Tosto G, Reitz C. Genome-wide association studies in Alzheimer’s disease: a review. Curr Neurol Neurosci Rep. 2013;13:381 https://doi.org/10.1007/s11910-013-0381-0. Epub 2013/08/21PubMed PMID: 23954969; PubMed Central PMCID: PMCPMC3809844.

5. Sariya S, Felsky D, Reyes-Dumeyer D, Lali R, Lantigua RA, Vardarajan B, et al. Polygenic risk score for Alzheimer’s Disease in Caribbean Hispanics. Ann Neurol. 2021. Epub 2021/05/27. https://doi.org/10.1002/ana.26131. PubMed PMID: 34038570.

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