Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning-Reference-Cited by-同舟云学术

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Published:2022-08-16 Issue:11 Volume:27 Page:4419-4431
ISSN:1359-4184
Container-title:Molecular Psychiatry
language:en
Short-container-title:Mol Psychiatry

Author:

Lahti Jari^ORCID,Tuominen Samuli^ORCID,Yang Qiong^ORCID,Pergola Giulio^ORCID,Ahmad Shahzad^ORCID,Amin Najaf,Armstrong Nicola J.,Beiser Alexa,Bey Katharina,Bis Joshua C.^ORCID,Boerwinkle Eric,Bressler Jan^ORCID,Campbell Archie^ORCID,Campbell Harry,Chen Qiang,Corley Janie^ORCID,Cox Simon R.^ORCID,Davies Gail^ORCID,De Jager Philip L.^ORCID,Derks Eske M.^ORCID,Faul Jessica D.,Fitzpatrick Annette L.,Fohner Alison E.,Ford Ian,Fornage Myriam^ORCID,Gerring Zachary^ORCID,Grabe Hans J.^ORCID,Grodstein Francine,Gudnason Vilmundur,Simonsick Eleanor,Holliday Elizabeth G.,Joshi Peter K.^ORCID,Kajantie Eero,Kaprio Jaakko^ORCID,Karell Pauliina,Kleineidam Luca,Knol Maria J.^ORCID,Kochan Nicole A.,Kwok John B.,Leber Markus,Lam Max,Lee Teresa,Li Shuo^ORCID,Loukola Anu,Luck Tobias^ORCID,Marioni Riccardo E.,Mather Karen A.^ORCID,Medland Sarah^ORCID,Mirza Saira S.,Nalls Mike A.,Nho Kwangsik,O’Donnell Adrienne,Oldmeadow Christopher,Painter Jodie^ORCID,Pattie Alison,Reppermund Simone,Risacher Shannon L.,Rose Richard J.,Sadashivaiah Vijay,Scholz Markus^ORCID,Satizabal Claudia L.^ORCID,Schofield Peter W.,Schraut Katharina E.,Scott Rodney J.^ORCID,Simino Jeannette,Smith Albert V.,Smith Jennifer A.^ORCID,Stott David J.,Surakka Ida,Teumer Alexander^ORCID,Thalamuthu Anbupalam,Trompet Stella^ORCID,Turner Stephen T.,van der Lee Sven J.,Villringer Arno^ORCID,Völker Uwe^ORCID,Wilson Robert S.,Wittfeld Katharina^ORCID,Vuoksimaa Eero,Xia Rui,Yaffe Kristine,Yu Lei,Zare Habil^ORCID,Zhao Wei^ORCID,Ames David,Attia John^ORCID,Bennett David A.,Brodaty Henry^ORCID,Chasman Daniel I.^ORCID,Goldman Aaron L.,Hayward Caroline^ORCID,Ikram M. Arfan^ORCID,Jukema J. Wouter^ORCID,Kardia Sharon L. R.,Lencz Todd^ORCID,Loeffler Markus,Mattay Venkata S.,Palotie Aarno^ORCID,Psaty Bruce M.^ORCID,Ramirez Alfredo^ORCID,Ridker Paul M.,Riedel-Heller Steffi G.^ORCID,Sachdev Perminder S.^ORCID,Saykin Andrew J.^ORCID,Scherer Martin,Schofield Peter R.^ORCID,Sidney Stephen,Starr John M.,Trollor Julian^ORCID,Ulrich William,Wagner Michael,Weir David R.^ORCID,Wilson James F.^ORCID,Wright Margaret J.^ORCID,Weinberger Daniel R.^ORCID,Debette Stephanie^ORCID,Eriksson Johan G.,Mosley Thomas H.,Launer Lenore J.^ORCID,van Duijn Cornelia M.^ORCID,Deary Ian J.^ORCID,Seshadri Sudha^ORCID,Räikkönen Katri

Abstract

Abstract Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

Funder

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Molecular Biology

Link

https://www.nature.com/articles/s41380-022-01710-8.pdf

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