White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals
-
Published:2019-11-29
Issue:4
Volume:25
Page:883-895
-
ISSN:1359-4184
-
Container-title:Molecular Psychiatry
-
language:en
-
Short-container-title:Mol Psychiatry
Author:
Koshiyama Daisuke, , Fukunaga Masaki, Okada Naohiro, Morita Kentaro, Nemoto Kiyotaka, Usui Kaori, Yamamori Hidenaga, Yasuda Yuka, Fujimoto Michiko, Kudo Noriko, Azechi Hirotsugu, Watanabe Yoshiyuki, Hashimoto Naoki, Narita HisashiORCID, Kusumi IchiroORCID, Ohi Kazutaka, Shimada Takamitsu, Kataoka Yuzuru, Yamamoto Maeri, Ozaki NorioORCID, Okada Go, Okamoto Yasumasa, Harada Kenichiro, Matsuo Koji, Yamasue Hidenori, Abe Osamu, Hashimoto RyuichiroORCID, Takahashi Tsutomu, Hori Tomoki, Nakataki Masahito, Onitsuka Toshiaki, Holleran Laurena, Jahanshad Neda, van Erp Theo G. M.ORCID, Turner Jessica, Donohoe Gary, Thompson Paul M., Kasai Kiyoto, Hashimoto RyotaORCID
Abstract
AbstractIdentifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophrenia; however, no similar cross-disorder study has been carried out to date. Here, we conducted mega-analyses comparing white matter microstructural differences between healthy comparison subjects (HCS; N = 1506) and patients with schizophrenia (N = 696), bipolar disorder (N = 211), autism spectrum disorder (N = 126), or major depressive disorder (N = 398; total N = 2937 from 12 sites). In comparison with HCS, we found that schizophrenia, bipolar disorder, and autism spectrum disorder share similar white matter microstructural differences in the body of the corpus callosum; schizophrenia and bipolar disorder featured comparable changes in the limbic system, such as the fornix and cingulum. By comparison, alterations in tracts connecting neocortical areas, such as the uncinate fasciculus, were observed only in schizophrenia. No significant difference was found in major depressive disorder. In a direct comparison between schizophrenia and bipolar disorder, there were no significant differences. Significant differences between schizophrenia/bipolar disorder and major depressive disorder were found in the limbic system, which were similar to the differences in schizophrenia and bipolar disorder relative to HCS. While schizophrenia and bipolar disorder may have similar pathological characteristics, the biological characteristics of major depressive disorder may be close to those of HCS. Our findings provide insights into nosology and encourage further investigations of shared and unique pathophysiology of psychiatric disorders.
Funder
Japan Agency for Medical Research and Development Ministry of Education, Culture, Sports, Science and Technology
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Psychiatry and Mental health,Molecular Biology
Reference64 articles.
1. Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;381:1371–9. 2. Purcell SM, Wray NR, Stone JL, Visscher PM, O’Donovan MC, Sullivan PF, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;460:748–52. 3. Rapoport J, Chavez A, Greenstein D, Addington A, Gogtay N. Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited. J Am Acad Child Adolesc Psychiatry. 2009;48:10–8. 4. Sullivan PF, Magnusson C, Reichenberg A, Boman M, Dalman C, Davidson M, et al. Family history of schizophrenia and bipolar disorder as risk factors for autism. Arch Gen Psychiatry. 2012;69:1099–03. 5. Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism. 2017;8:21.
Cited by
156 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|