Preclinical safety profile of sildenafil

Author:

Abbott D,Comby P,Charuel C,Graepel P,Hanton G,Leblanc B,Lodola A,Longeart L,Paulus G,Peters C,Stadler J

Publisher

Springer Science and Business Media LLC

Subject

Urology

Reference21 articles.

1. USFDA. Center for Drug Evaluation and Research Application Number NDA 20-895 Pharmacology Reviews.

2. CPMP/1136/98 rev 2 Scientific Discussion ©EMEA. 2000.

3. ICH: Guidance on Non-Clinical Safety Evaluation.

4. Nicholson CD, Challiss RAJ, Shahid M . Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 1991; 12: 19–27.

5. Geelen P et al. Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current. Circulation 2000; 102: 275–277.

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