Phase 3 data for PCSK9 inhibitor wows
Author:
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
http://www.nature.com/articles/nbt1213-1057.pdf
Reference4 articles.
1. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
2. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
3. Molecular Characterization of Loss-of-Function Mutations in PCSK9 and Identification of a Compound Heterozygote
4. Sequence Variations inPCSK9,Low LDL, and Protection against Coronary Heart Disease
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1. PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages;Journal of Experimental & Clinical Cancer Research;2022-10-14
2. Pro-protein convertase subtilisin/kexin type 9 promotes intestinal tumor development by activating Janus kinase 2/signal transducer and activator of transcription 3/SOCS3 signaling in ApcMin/+ mice;International Journal of Immunopathology and Pharmacology;2021-01
3. The LDL-Receptor and its Molecular Properties: From Theory to Novel Biochemical and Pharmacological Approaches in Reducing LDL-cholesterol;Current Medicinal Chemistry;2020-02-18
4. Neurovascular dysfunction in vascular dementia, Alzheimer’s and atherosclerosis;BMC Neuroscience;2018-10-17
5. Diversity and inclusion in genomic research: why the uneven progress?;Journal of Community Genetics;2017-07-18
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