Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/s41573-020-0071-y.pdf
Reference238 articles.
1. Yuan, J., Amin, P. & Ofengeim, D. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nat. Rev. Neurosci. 20, 19–33 (2019). This review summarizes what is currently known about the role of RIPK1 in neurological diseases.
2. Ofengeim, D. & Yuan, J. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat. Rev. Mol. Cell Biol. 14, 727–736 (2013).
3. Ofengeim, D. et al. Activation of necroptosis in multiple sclerosis. Cell Rep. 10, 1836–1849 (2015). This paper provides the first evidence for the role of RIPK1 in a chronic autoimmune disease with neurodegeneration — MS.
4. Ito, Y. et al. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science 353, 603–608 (2016). This paper provides the first genetic connection of RIPK1 kinase and necroptosis with ALS.
5. Caccamo, A. et al. Necroptosis activation in Alzheimer’s disease. Nat. Neurosci. 20, 1236–1246 (2017).
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