Circadian rhythm as a therapeutic target
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/s41573-020-00109-w.pdf
Reference250 articles.
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2. Bargiello, T. A., Jackson, F. R. & Young, M. W. Restoration of circadian behavioural rhythms by gene transfer in Drosophila. Nature 312, 752–754 (1984). This article demonstrates that introduction of a DNA fragment from a per+ fly encoding a 4.5-kb poly(A)+ RNA (later known as per) in a per0 (arrhythmic) fly can restore its circadian rhythmicity.
3. Hardin, P. E., Hall, J. C. & Rosbash, M. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343, 536–540 (1990). This landmark article identifies a feedback loop through which the cyclic per RNA level is regulated by its own protein activity.
4. Takahashi, J. S. Transcriptional architecture of the mammalian circadian clock. Nat. Rev. Genet. 18, 164–179 (2017).
5. Schroeder, A. M. & Colwell, C. S. How to fix a broken clock. Trends Pharmacol. Sci. 34, 605–619 (2013).
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