Drug targeting in psychiatric disorders — how to overcome the loss in translation?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.nature.com/articles/s41573-023-00847-7.pdf
Reference145 articles.
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2. Marder, S. R., Laughren, T. & Romano, S. J. Why are innovative drugs failing in phase III? Am. J. Psychiatry 174, 829–831 (2017).
3. Spark, D. L., Fornito, A., Langmead, C. J. & Stewart, G. D. Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics. Transl. Psychiatry 12, 147 (2022).
4. Tricklebank, M. D., Robbins, T. W., Simmons, C. & Wong, E. H. F. Time to re-engage psychiatric drug discovery by strengthening confidence in preclinical psychopharmacology. Psychopharmacology 238, 1417–1436 (2021).
5. Correll, C. U. et al. The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de-risk trial programmes of novel agents. World Psychiatry 22, 48–74 (2023).
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